Palmitoylethanolamide;PEA;CAS 544-31-0


Palmitoylethanolamide;PEA;CAS 544-31-0

Product No.:GIHI-001

  • Details
Our factory has been producing Palmitoylethanolamide powder for many years. As the earliest and biggest manufacturer of PEA , CAS: 544-31-0 palmitoylethanolamide bulk powder, we have FDA register No, and we also have ISO on it.
For the qualtity, our Palmitoylethanolamide powder was tested in USA lab and our assay of PEA is very high, could be 99%.

Palmitoylethanolamide Bulk Powder (CAS 544-31-0) Synonym
CAS: 544-31-0
EC No.: 208-867-9
MF: C18H37NO2
MW: 299.49

100g/bag; 500g/bag; 1kg/bag; 25kg/drum
Recommended storage method:
Store in a cool, dry and ventilated place.
Recommended storage temperature:
2 - 8 °C
Product usage:
Dietary supplements, anti-inflammatory agents

Palmitoylethanolamide Powder (CAS 544-31-0) Parameters

Test Item



White to light-yellow crystalline solid

Melt point()










Total plate count

10cfu/g Max

Yeast and Molds

10cfu/g Max

Heavy metals

Lead :3ppm Max

Mercury:0.1ppm Max

Cadmium:1ppm Max


Residue solvents

No any solvents exist

Particle size




Palmitoylethanolamide Powder (CAS 544-31-0) Functions
Anti-Inflammatory and Analgesic
Improve the ability of immunity
Treating chronic pain
Treating epilepsy, cerebral ischemia and stroke

Palmitoylethanolamide Bulk Powder (CAS 544-31-0) More Information

What is Palmitoylethanolamide Powder (CAS 544-31-0)?
Palmitoylethanolamide, produced in the body, is a natural painkiller ingredient in the endogenous fatty acid amide category and synthesized within your own body. We call it endogenous. Palmitoylethanolamide pea powder is widely applied in sports nutrition supplements and joint health formulas worldwide, especially in the United States, Australia, UK, Canada, Netherlands, Belgium, Italy, France, Germany, Brazil, India, Swissland, Russia and many other countries.

Its mechanism of action was discovered by the Nobel laureate professor Rita Levi-Montalcini, and its chemical structure is as follows:

Chemical Structure Of Palmitoylethanolamide

Chemical Structure Of Palmitoylethanolamide

PEA is a special natural substance; Nobel Prize holder LeviMontalcini discovered its effect and she also described its value in treating chronic infections and pains. Following her discovery, hundreds of scientific studies have been carried out, which elaborate on her research results.

PEA is a natural substance with a long-term effect that corresponds with the natural healing power of our body.
PEA has been described in more than 700 scientific publications.
PEA was described in 1957 for the first time.
PEA has already been used by more than a million people all over the world.
PEA can be used in combination with other products without any problems.
PEA is a natural substance.
PEA is produced in our body.
PEA can be found in food such as meat, eggs, soybeans and peanuts.

Our patent synthesis method to ensure our raw Palmitoylethanolamide is usually in flake form, the only one company in the world who could make this kind flake Palmitoylethanolamide. Our patent synthesis method make our Palmitoylethanolamide do not have any chemical solvents residue because we did not use any chemicals solvents to produce our Palmitoylethanolamide. So, GIHI Chemicals Palmitoylethanolamide is healthier for human.

Palmitoylethanolamide is practically insoluble in water and poorly soluble in most other aqueous solvents. In the workd market,there are four main dosage formulations of palmitoylethanolamide:
Soft gels

Palmitoylethanolamide food sources

Palmitoylethanolamide Food Sources
Soy lecithin, soybean, egg yolk, peanut (Arachis hypogaea), and Medicago sativa are the top food sources. However, the calculating weight unit is ng/g (nanogram/gram). 6700 ng/g is equal to 6.7mg/kilo, this means  that only 6.7mg PEA is in 1 kilo of soybean. The concentration of palmitoylethanolamide in natural foods are too low to meet our daily need. So,that is why we need to take some PEA from PEA capsule or other containing PEA formulation products.

Palmitoylethanolamide Bulk Powder (CAS 544-31-0) safety status

Palmitoylethanolamide and FDA
Palmitoylethanolamide pea powder is marked as a dietary supplement ingredient in the United States. FDA has a flexible policy upon dietary ingredients. Federal law does not require dietary supplements to be proven safe to FDA’s satisfaction before they are marketed. As long as the ingredient can be found in the human body metabolic process, palmitoylethanolamide pea powder is regarded as safe to be used.
Palmitoylethanolamide is naturally occurring in your body, and can also be found in many food sources. It is safe to be supplemented to the body. More than 400 studies and clinical trials are conducted; no serious side effects have been reported yet.
Moreover, there are hundreds of palmitoylethanolamide supplements on sales on supplement stores Amazon, Vitamin Shoppe, iHerb, GNC, etc.
Palmitoylethanolamide pea powder is not to treat cure or prevent disease, and there is no GRAS notice for palmitoylethanolamide powder for the time being. However, it is still safe to use PEA supplements.

European Medicines Agency (EMA) regulation
In some European countries like Italy, Germany, and Spain, palmitoylethanolamide is commercially advertised as dietary food for special medical purposes (AFMS). Just name some trademarks for your reference, such as PeaVera™ from JP Russell Science), Normast® of Epitech and Visimast® from Medivis.
In Italy, The Italian Ministry of Health has recently revised its two food supplement guidelines on permitted daily levels of vitamins and minerals and nutrients and other substances with a nutritional or physiological effect.
It is also interesting to note that Palmitoylethanolamide has been proved to be devoid of adverse effects, even if used for prolonged periods and/or administered to fragile subjects. That’s why Palmitoylethanolamide (PEA) is added to the list of substances for use in food supplements without defined maximum limits.

Palmitoylethanolamide clinical trials
More than 700 clinical studies on Palmitoylethanolamide has been extensively carried out in the past decades. These studies demonstrate objective improvements in nerve function, chronic pain, neuropathic pain, and chronic inflammation, and other anti inflammatory benefits, etc.

The literature is listed as below:
The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review.
Efficacy of ultra-micronized palmitoylethanolamide (um-PEA) in geriatric patients with chronic pain: study protocol for a series of N-of-1 randomized trials.
Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis.
Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy.

Palmitoylethanolamide Bulk Powder (CAS 544-31-0) specifications
There are various PEA specifications available, such as powder form, topical cream, capsule, tablet, etc.
Our popular specs are flake and ultramicronized Palmitoylethanolamide forms.
Both are dietary supplement grade and pharmaceutical grade that can be used in supplements and medicines directly. The difference lies in the particle size.
Ultramicronized Palmitoylethanolamide powder has a particle size ranges less than 10 microns ( μm).

Palmitoylethanolamide Bulk Powder (CAS 544-31-0) Mechanism of Action
Palmitoylethanolamide works by affecting various receptors directly or indirectly, such as PPAR-a, CB1, CB2, GPR119, GPR55, etc.

Action Of Palmitoylethanolamide
Palmitoylethanolamide blocks the excessive activity of mast cells and glial cells and restores their normal activity. By the way, Palmitoylethanolamide also cuts down the activity of the pro-inflammatory enzyme COX. There are more mechanisms showing how palmitoylethanolamide works (listed in the very bottom of this page.)

Palmitoylethanolamide Bulk Powder (CAS 544-31-0) Benefits
1. Anti-Inflammatory and Analgesic;
2. Improve the ability of immunity;
3. Treating chronic pain;
4. Treating epilepsy, cerebral ischemia and stroke;
5. Treating Alzheimer's disease and Parkinson's disease.
PEA for Neuropathic Pain
In one pivotal, double-blind, placebo-controlled trial in 636 sciatic pain patients, pain intensity is strongly reduced by 50% after 3 weeks of treatment.
No drug interactions or troublesome side effects have been described so far.

PEA for anti-inflammatory purpose
Inflammation means pain. The inflammatory process is of great significance in the development of Neuropathic Pain.
Palmitoylethanolamide is an anti-inflammatory and pro-resolving lipid mediator that turns down mast cell activation and regulates glial cell behaviors. The sustained imbalance between pro-inflammatory and pro-resolving mediators shows that chronic neuroinflammation is happening.

Dietary Supplement containing Palmitoylethanolamide Bulk Powder (CAS 544-31-0)
If you check all the nutritional products markets, you’ll find various PEA supplement products available, some in capsules, some in tablets, some even in powder forms; some are in a single ingredient formula, some are blended with other joint health compounds. Below are some typical examples of PEA forms and their respective dose information:

Some Palmitoylethanolamide(PEA) brands on the market:
Palmitoylethanolamide(PEA) Capsule: 400mg/capsule for human usage.

Palmitoylethanolamide Capsule

Palmitoylethanolamide(PEA) powder mixed with B series nutritional compounds:

Palmitoylethanolamide Powder
Ingredients Of PEA
Palmitoylethanolamide Cream
Detail Of PEA

Palmitoylethanolamide Chewable Tablet Form
Palmitoylethanolamide Bulk Powder (CAS 544-31-0) chewable tablet form:
One tablet contains 600mg palmidrol PEA, and the dose is one to two tablets a day, that's 600mg to 1200mg daily.

PEA Supplement Facts

This PEA formula is Palmitoylethanolamide 600mg with 300mg Turmeric Root Extract (95% curcuminoids) per serving. (per day)

PEA Formula

Joint Formula Powder

Methylsulfonylmethane (MSM), Turmeric Extract (Root), Hyaluronic Acid and Palmitoylethanolamide are the four main active ingredients in this joint health powder formula. The daily intake of PEA is 600mg as well.

Joint Formula Powder MSM
Mirica Natural Pain Relief Formula
MSM Joint Formula Powder

Does Palmitoylethanolamide Powder (CAS 544-31-0) Have Side effects?
Palmitoylethanolamide is naturally exciting and is one part of the human body. The EU has no limit on the dosing quantity of Palmitoylethanolamide every day. No serious adverse
palmidrol side effects. However, palmitoylethanolamide is not evaluated by the FDA, and is not intended to diagnose treat cure disease.
have been reported yet. However, palmitoylethanolamide is not evaluated by the FDA, and is not intended to diagnose treat cure disease.

How to buy ultra micronized Palmitoylethanolamide Bulk Powder (CAS 544-31-0)?

GIHI Chemicals co., limited, is a professional manufacturer of ultra micronized palmitoylethanolamide(PEA) powder, we could produce 10000kg per two weeks. And we have a lot of experience in exporting our ultra micronized palmitoylethanolamide(PEA) powder able to ship to every country by courier, by air, by sea or other shipping methods.

If you want to buy bulk quantity, please contact us directly by email to:, or contact us by phone: 0086-571-86217390.

What kind of testing documents you could get from us?
Our ultra micronized palmitoylethanolamide(PEA) powder ( CAS 544-31-0) has been tested by trusted and authoritative Third-Party Testing labs and organizations on the following items:
1. Purity
2. Heavy Metals
3. Residual Solvents
4. NMR spectrum
5. Microorganism testing (Microbiology testing)

Third Party Testing Labs Gihi

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